医学
脂质过氧化
依那普利
丙二醛
氯沙坦
肾
肾缺血
缺血
血管紧张素II
肾动脉
内科学
内分泌学
再灌注损伤
泌尿科
血管紧张素转换酶
药理学
氧化应激
受体
血压
作者
Yuyen Seujang,Wipawee Kittikowit,Somchai Eiam‐Ong,Somchit Eiam-Ong
出处
期刊:PubMed
日期:2006-10-01
卷期号:89 (10): 1686-93
被引量:5
摘要
To investigate the role of angiotensin inhibition on lipid peroxidation (LPO) and renal pathology in ischemic reperfusion (IR).Male Wistar rats were subjected to 15-, 30-, 45- or 60- minutes ofrenal ischemia (I) by left renal artery occlusion. In the 30-minute I group, reperfusion (R) for I day (13,R) was performed in additional animals that had been treated with water, angiotensin converting enzyme inhibitor (ACE]; enalapril 5 mg/kg/d), or angiotensin receptor type 1 blocker (ARB; losartan 10 mg/kg/d) one day before I and were continued for 1 day after R. Renal tissue malondialdehyde (MDA), an indicator of LPO, was examined during I and IR periods. Renal pathology was also determined.During ischemia, renal tissue MDA levels were increased throughout the 60-minute ischemic period and was maximum at 30 minutes of ischemia (p < 0.01). Histological changes in 30-minutes I group showed slight tubular cell congestion and mild interstitial edema. One day after reperfusion, MDA levels were still elevated (p < 0. 01) when compared with sham. Progression of renal pathology was observed after I day of reperfusion. Both ACEI and ARB could attenuate the heightened MDA levels (p < 0.01). IR-induced renal injury was markedly diminished by administration ofACEI as well as by ARB.These results indicate that inhibition of angiotensin could reduce lipid peroxidation and ameliorate renal injury during IR condition.
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