The vapor pressure of HFE 7100 was measured from (306 to 431) K for pressures from (36 to 1180) kPa using a Burnett apparatus. The temperature measurement uncertainty was estimated to be ± 5 mK, and the pressure uncertainty was estimated to be ± 300 Pa. A Wagner-type equation was used for the vapor pressure of HFE 7100 based on the experimental data. This equation contains five coefficients and correlates the measured vapor pressures within 0.11 %.