菌核病
化学
抗真菌
菌丝体
EC50型
烟酰胺
铅化合物
立体化学
体内
质子核磁共振
体外
生物化学
微生物学
酶
生物
植物
生物技术
作者
Wei Wang,Xiang-Jia Liu,Guo-Tai Lin,Ji-Peng Wu,Gong Xu,Dan Xu
标识
DOI:10.1002/cbdv.202101032
摘要
To discover more effective antifungal agents, twenty N-(1H-pyrazol-5-yl)nicotinamide derivatives were designed, synthesized, and structurally confirmed by 1 H-NMR, 13 C-NMR, and ESI-MS. All target compounds were evaluated for their antifungal activities by mycelia growth inhibition. Preliminary screening results displayed that many of these compounds had good fungicidal activity to S. sclerotiorum and V. mali. Compound B4 exhibited antifungal activity against S. sclerotiorum and V. mali with EC50 values of 10.35 and 17.01 mg/L, respectively. The experiment in vivo identified that compound B4 was effective for suppressing rape sclerotinia rot caused by S. sclerotiorum at 50 mg/L. The molecular docking study and scanning electron microscopy preliminary clarified the possible antifungal mechanism of compound B4.
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