促炎细胞因子
三阴性乳腺癌
细胞外小泡
免疫系统
炎症
细胞外
乳腺癌
癌症研究
癌症
微泡
人体乳房
巨噬细胞
免疫学
生物
医学
细胞生物学
内科学
体外
生物化学
小RNA
基因
作者
Mercedes Tkach,Jessie Thalmensi,Eleonora Timperi,Paul Gueguen,Nathalie Névo,Eleonora Grisard,Philémon Sirven,Federico Cocozza,Alizée Gouronnec,Lorena Martín‐Jaular,Mabel Jouve San-Roman,Fabien Delisle,Nicolas Manel,Derek C. Rookhuizen,Coralie L. Guerin,Vassili Soumelis,Emanuela Romano,Élodie Segura,Clotilde Théry
标识
DOI:10.1073/pnas.2107394119
摘要
Significance Our work uncovers mechanisms by which tumor cells impact tumor-associated macrophages in human triple-negative breast cancer. Via extracellular vesicles (EVs), these tumors promote macrophages with proinflammatory features, correlated with better clinical outcome. Our results suggest exploration of these EVs as tools, alone, or in combination with other therapies, to promote a favorable environment for the generation of anti-tumor immune responses.
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