The main intention of these studies was to formulate and evaluate a novel herbal cream which includes Senna alata,Wrightia tinctoria and Datura metel for the treatment of secondary skin infections. The most suitable route for skin infection is topical. The development of topical drug transport systems designed to have systemic results appears to be useful for a number of drugs as a result of the numerous advantages over traditional routes of drug administration. In this study a novel herbal cream formulation consisting of Senna alata,Wrightia tinctoria and Datura metel was prepared. This study was subjected to in-vitro diffusion method. Microbiological studies were carried out the safety of materials used inside the formulation. The formulated cream was found to be safe and effective for the treatment of skin infection.