硼氢化
化学
金属转移
对映选择合成
催化作用
无水的
镍
产量(工程)
有机化学
氢化物
组合化学
金属
冶金
材料科学
作者
Hai N. Tran,Levi M. Stanley
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-12-14
卷期号:24 (1): 395-399
被引量:4
标识
DOI:10.1021/acs.orglett.1c04073
摘要
The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.
科研通智能强力驱动
Strongly Powered by AbleSci AI