孟德尔随机化
心情
医学
抗磷脂综合征
神经质
哮喘
人口
情绪障碍
系统性红斑狼疮
临床心理学
免疫学
内科学
人格
精神科
焦虑
心理学
疾病
基因型
遗传学
生物
遗传变异
抗体
基因
环境卫生
社会心理学
作者
Huahua Zhong,Xiao Huan,Kexin Jiao,He Shen,Wen Zhu,Rui Zhao,Li-Ying Goh,Manqiqige Su,Jie Song,Chong Yan,Jian-Ying Xi,Xueying Zheng,Zhirui Zhou,Sushan Luo,Chongbo Zhao
标识
DOI:10.1016/j.autrev.2022.103214
摘要
The interrelationship between mental health and autoimmunity gains more and more attention in recent years. However, the causality between personality traits and autoimmune diseases remained largely unknown.We first conducted two-sample mendelian randomization (MR) analysis on the relationships between mood instability, which is a common personality trait in the general population, and 10 autoimmune diseases. The results were further validated in secondary analyses of sensitivity where different MR methods, ethnicities, genders, and ascertainment methods were compared.In the primary analyses, three autoimmune diseases showed genetical predisposition to mood instability: asthma (OR [95%CI] = 3.45 [2.48, 4.78], P = 1.33E- 13), hypothyroidism (OR [95%CI] = 1.02 [1.00, 1.03], P = 1.71E-02), and systemic lupus erythematosus (OR [95%CI] = 5.25 [1.21, 22.76], P = 2.67E-02). The results were consistent in subsequent secondary analyses. Three diseases remained significantly correlated with mood instability by different MR methods with asthma remaining significant in Finnish and mixed populations, and in females from the UK biobank, while hypothyroidism remained significant in both genders from the UK biobank.Mood instability is a modifiable risk factor for three autoimmune diseases including asthma, hypothyroidism and systemic lupus erythematosus.
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