增食欲素
PI3K/AKT/mTOR通路
食欲素受体
信号转导
生物
能量稳态
效应器
食欲素-A
神经科学
Wnt信号通路
细胞生物学
神经肽
受体
生物化学
作者
Ying Song,Beibei Wang,Wenjun Wang,Qiwen Shi
标识
DOI:10.1016/j.tem.2023.02.008
摘要
Orexin (OX)A and OXB are a pair of neuropeptides secreted by orexin-producing neurons in the lateral hypothalamus. The orexin system can regulate many physiological processes through these two receptor pathways, such as feeding behavior, sleep/wake state, energy homeostasis, reward, and the coordination of emotion. Mammalian target of rapamycin (mTOR) can coordinate upstream signals with downstream effectors, thereby regulating fundamental cellular processes and also plays an essential role in the signaling network downstream of the orexin system. In turn, the orexin system can activate mTOR. Here, we review the association of the orexin system with the mTOR signaling pathway mainly by discussing that drugs in various diseases exert their effects on the orexin system, indirectly affecting the mTOR signaling pathway.
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