免疫学
百日咳博德特菌
医学
百日咳
免疫
百日咳疫苗
免疫
抗体
接种疫苗
病毒学
免疫系统
生物
遗传学
细菌
作者
Pauline Schmitt,Lisa Borkner,Seyed Davoud Jazayeri,K. McCarthy,Kingston H.G. Mills
标识
DOI:10.1016/j.coi.2023.102355
摘要
Whooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acellular pertussis (aP) vaccines induce potent circulating IgG and prevent severe disease in children/adults and in infants born to vaccinated mothers. However, they do not prevent nasal infection, allowing asymptomatic transmission of B. pertussis. Studies in animal models have demonstrated that, unlike natural infection, immunization with aP vaccines fails to induce secretory immunoglobulin A (IgA) or interleukin-17 (IL-17)-secreting tissue-resident memory CD4 T (TRM) cells, required for sustained sterilizing immunity in the nasal mucosa. Live-attenuated vaccines or aP vaccines formulated with novel adjuvants that induce respiratory IgA and TRM cells, especially when delivered by the nasal route, are in development and have considerable promise as next-generation vaccines against pertussis.
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