MARVEL domain containing CMTM4 affects CXCR4 trafficking

Defective zebrafish cmtm4 slowed the development of the posterior lateral line (pLL) by altering the Cxcr4b gradient across the pLL primordium (pLLP). Analysis in mammalian cells uncovered that CMTM4 interacted with CXCR4 and altered its glycosylation pattern but did not affect internalization or degradation of CXCR4.