信使核糖核酸
RNA结合蛋白
细胞生物学
功能(生物学)
势垒函数
生物
核糖核酸
肠上皮
化学
上皮
生物化学
基因
遗传学
作者
Shelley R. Wang,Caroline G. Mallard,Cassandra A. Cairns,Hee Kyoung Chung,Doo-Yeol Yoo,Suraj Jaladanki,Lan Xiao,Jianying Wang
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2023-12-01
卷期号:325 (6): G518-G527
标识
DOI:10.1152/ajpgi.00143.2023
摘要
The current study shows that polyamines stabilize the Cx43 mRNA via HuR, thus enhancing the function of the Cx43-mediated gap junction. These findings suggest that induced Cx43 by HuR plays a critical role in the process by which polyamines regulate intestinal epithelial barrier.
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