海马结构
召回
接口(物质)
海马体
情景记忆
心理学
心理意象
认知
计算机科学
认知心理学
虚拟现实
人机交互
认知科学
神经科学
气泡
最大气泡压力法
并行计算
作者
Chongxi Lai,Shinsuke Tanaka,Timothy D Harris,Albert K. Lee
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-11-03
卷期号:382 (6670): 566-573
被引量:5
标识
DOI:10.1126/science.adh5206
摘要
The hippocampus is critical for recollecting and imagining experiences. This is believed to involve voluntarily drawing from hippocampal memory representations of people, events, and places, including maplike representations of familiar environments. However, whether representations in such "cognitive maps" can be volitionally accessed is unknown. We developed a brain-machine interface to test whether rats can do so by controlling their hippocampal activity in a flexible, goal-directed, and model-based manner. We found that rats can efficiently navigate or direct objects to arbitrary goal locations within a virtual reality arena solely by activating and sustaining appropriate hippocampal representations of remote places. This provides insight into the mechanisms underlying episodic memory recall, mental simulation and planning, and imagination and opens up possibilities for high-level neural prosthetics that use hippocampal representations.
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