Patients With Muscle-Invasive Bladder Cancer With Lymphovascular Invasion in Transurethral Resection Specimen Benefits Most From Platinum-Based Neoadjuvant Chemotherapy

淋巴血管侵犯 医学 膀胱切除术 膀胱癌 肿瘤科 队列 比例危险模型 内科学 泌尿科 化疗 癌症 外科 转移
作者
Ziwei Wang,Wen He,Yidie Ying,Maoyu Wang,Qing Chen,Zhensheng Zhang,Shuxiong Zeng,Chuanliang Xu
出处
期刊:Clinical Genitourinary Cancer [Elsevier]
标识
DOI:10.1016/j.clgc.2023.10.014
摘要

The survival benefit of neoadjuvant chemotherapy (NAC) before definitive radical cystectomy (RC) varied among patients, suggesting proper selection of patients for NAC to maximize the survival benefit. This study aimed to investigate the role of lymphovascular invasion (LVI) in transurethral resection (TUR) specimens in selecting patients with MIBC for NAC.Two retrospective cohorts of patients with cT2-4aN0 MIBC who underwent RC from 2004 to 2015 provided by Lund University were included. Inverse probability weighting was applied to make the NAC-treated (NAC) and untreated (non-NAC) cohorts comparable. Survival benefits were estimated with Kaplan-Meier curves and Cox proportional hazards models. The primary endpoint was cancer-specific survival (CSS). LVI in TUR specimens and molecular taxonomies (BASE47, UNC, and LundTax) were examined, and bulk RNA-seq datasets were explored for LVI-relevant signatures.A total of 341 patients with cT2-4aN0 MIBC were included. The NAC cohort included 125 patients, whereas the non-NAC cohort included 216 patients. The 3-year CSS benefit of NAC was 7.1%. For patients with positive LVI in TUR specimens, the 3-year CSS benefit of NAC was 26.2% (48.1% vs. 74.3%), with a risk reduction of 56% (HR = 0.44, P = .03). A sensitivity analysis confirmed a significant interaction between LVI and NAC. This study failed to identify the molecular subtypes that maximized the survival benefit of NAC. Exploration of LVI-relevant signatures remains inconclusive.LVI in TUR specimens could help identify patients with MIBC who would derive maximal survival benefit from NAC. Further prospective validation is necessary.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Jasper应助等待惜文采纳,获得10
1秒前
英姑应助Soche采纳,获得10
1秒前
2秒前
2秒前
执着烧鹅完成签到,获得积分10
3秒前
5秒前
阿斯顿发布了新的文献求助10
7秒前
佳丽发布了新的文献求助10
7秒前
SciGPT应助落后访烟采纳,获得10
7秒前
penguin君发布了新的文献求助10
8秒前
8秒前
科研通AI2S应助radish采纳,获得10
8秒前
1111发布了新的文献求助10
9秒前
9秒前
CodeCraft应助溪地采纳,获得10
11秒前
12秒前
12秒前
13秒前
14秒前
14秒前
15秒前
司空剑封发布了新的文献求助10
16秒前
凤梨完成签到,获得积分10
16秒前
佳丽完成签到,获得积分10
17秒前
18秒前
19秒前
Amos发布了新的文献求助10
20秒前
23秒前
luluyu完成签到,获得积分10
26秒前
大老虎完成签到,获得积分10
27秒前
zhouzhou打工人完成签到,获得积分10
29秒前
正破发布了新的文献求助10
30秒前
30秒前
罗_应助大老虎采纳,获得10
31秒前
乐乐应助li采纳,获得10
31秒前
myffff完成签到 ,获得积分10
34秒前
多肉完成签到,获得积分10
35秒前
脑洞疼应助晴小晴采纳,获得10
35秒前
35秒前
优秀笑柳发布了新的文献求助10
35秒前
高分求助中
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Chinese-English Translation Lexicon Version 3.0 500
Electronic Structure Calculations and Structure-Property Relationships on Aromatic Nitro Compounds 500
マンネンタケ科植物由来メロテルペノイド類の網羅的全合成/Collective Synthesis of Meroterpenoids Derived from Ganoderma Family 500
薩提亞模式團體方案對青年情侶輔導效果之研究 400
[Lambert-Eaton syndrome without calcium channel autoantibodies] 400
Statistical Procedures for the Medical Device Industry 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2380160
求助须知:如何正确求助?哪些是违规求助? 2087395
关于积分的说明 5241149
捐赠科研通 1814595
什么是DOI,文献DOI怎么找? 905230
版权声明 558734
科研通“疑难数据库(出版商)”最低求助积分说明 483276