透皮
渗透
药品
高分子
药物输送
药理学
化学
医学
生物化学
有机化学
膜
作者
Prabhudutta Panda,Ashok Kumar Sahu
出处
期刊:International Journal of Advanced Pharmaceutical Sciences and Resarch (IJAPSR)
[Blue Eyes Intelligence Engineering and Sciences Engineering and Sciences Publication - BEIESP]
日期:2023-10-30
卷期号:3 (6): 1-11
被引量:1
标识
DOI:10.54105/ijapsr.f4028.103623
摘要
The various transdermal drug delivery method, allows medications to cross the biological barriers and enter the bloodstream to elicit desired pharmacological response. The relevant article focuses on the numerous biological and other macromolecule-based permeation enhancers including carbohydrates, protein-peptides and lipids used in transdermal drug delivery. Though the focus of the study is on role of macromolecule, as well as their mechanisms and modes of action for efficient transdermal drug delivery, it also concentrates on the recent developments in various permeation enhancement techniques. Transdermal administration of weakly permeable medications with shorter biological half-lives typically makes use of the permeation augmentation techniques and agents, which should not have any explicit toxicological implications and incompatibility within the formulations. In this review, limelight has been given to the promising permeation enhancers of current scenario which consist of various macromolecules.
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