医学
肥胖
无排卵
生育率
不育
内分泌学
胰岛素抵抗
脂肪组织
体外受精
内科学
妇科
生理学
怀孕
多囊卵巢
生物
人口
环境卫生
遗传学
作者
Abigail Armstrong,Marisa Berger,Zain Al-Safi
出处
期刊:Current Opinion in Obstetrics & Gynecology
[Ovid Technologies (Wolters Kluwer)]
日期:2022-06-27
卷期号:34 (4): 184-189
被引量:5
标识
DOI:10.1097/gco.0000000000000794
摘要
The objective of this review is to highlight the recent literature on how obesity affects reproductive capacity in men and women.The relationship between fertility and obesity is complex and involves the hypothalamic-pituitary-ovarian axis, neuroendocrine systems and adipose tissue. The exact pathophysiology of how obesity lowers fertility rates is unknown, but likely multifactorial involving anovulation, insulin resistance and alterations in gonadotropins. In addition, there is controversy on whether oocyte quality or endometrial receptivity plays a larger role in obese infertile women. Data on effects of bariatric surgery and weight loss on obese infertile men and women are mixed.Obesity alters the hormonal profile, gonadotropin secretion, embryo development and in-vitro fertilization outcomes in both men and women.
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