Amoebicidal action of isoliquiritigenin and glabridin from Glycyrrhiza species: Mechanisms and effects against Acanthamoeba castellanii

These findings suggest that ISL and GLA, two components of Glycyrrhiza species, may possess activity against A. castellanii trophozoites. Our findings suggest that ISL suppresses trophozoites by regulating NAD⁺ metabolism, while GLA inhibits trophozoites through the regulation of sterol metabolism.