癌症研究
调节器
胰腺癌
腺癌
医学
DNA修复
靶向治疗
胰腺导管腺癌
癌症
DNA损伤
DNA
DNA损伤修复
癌症治疗
信号转导
遗传增强
后天抵抗
化疗
突变
抗药性
作者
Changying Li,X.-M. Zhao,Xinyan Li,Chunyan Wang,Zhenyu Huo,Xin Xu,Wenjuan Kang,Somaira Nowsheen,Khaled Aziz,Guang-Yi Sun,Zhihua Liu,Zhenkun Lou,Min Deng
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-11-03
卷期号:86 (3): 730-745
标识
DOI:10.1158/0008-5472.can-25-1435
摘要
The ATM-TGS1-BRCA1 signaling axis is a critical regulator of DNA repair that can be targeted to overcome genotoxic therapy resistance, providing a promising therapeutic strategy that could transform pancreatic cancer treatment.
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