医学
嗜酸性粒细胞增多
肉芽肿伴多发性血管炎
嗜酸性
美波利祖马布
嗜酸性粒细胞增多症
鼻息肉
嗜酸性粒细胞增多综合征
嗜酸性食管炎
嗜酸性粒细胞
特应性皮炎
背景(考古学)
哮喘
免疫学
皮肤病科
疾病
病理
血管炎
古生物学
生物
作者
Andrea Marra,C.A. Sgoifo Rossi,M. Piga,Gianluca Moroncini,Maria Beatrice Bilò
出处
期刊:European annals of allergy and clinical immunology
[Edra SpA]
日期:2024-03-01
卷期号: (online first)
标识
DOI:10.23822/eurannaci.1764-1489.339
摘要
Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), less common primary eosinophilic disorders of gastrointestinal tract, and rare conditions including eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). A literature search was carried out in January 2024 in the MEDLINE and Scopus databases using the PubMed search engine (PubMed, National Library of Medicine, Bethesda, MD). We focused on blood eosinophilia and hypereosinophilia. A diagnostic workup is proposed. From allergist's point of view, we focused the review on 4 groups of eosinophilic disorders of specific interest. Our increased understanding of type 2 inflammation and biology has recently led to development of highly effective precision targeted therapies that are now approved for a growing number of eosinophilic disorders. Novel targeted biologics have a major impact on treatment strategies and have resulted in major advances in our understanding of the pathogenesis of these disorders. In the context of EADs, according to the heterogeneity of eosinophilic disorders a multidisciplinary approach should be adopted. Allergists and Clinical Immunologists play an important role as they have a clear understanding of the eosinophilic inflammation and the role of cytokines and are trained to recognize and characterize type 2 (T2) inflammation and its associated pathologies.
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