生物
清脆的
胚胎干细胞
Cas9
细胞生物学
干细胞
串扰
细胞命运测定
细胞
遗传学
基因
转录因子
物理
光学
作者
Qian Li,Liqun Shao,Luo Li,Seung-Beom Han,Yu You,Zhenya Shen
标识
DOI:10.1016/j.scr.2022.102942
摘要
BMP10 signaling has been implicated in regulation of cardiovascular cell fate determination and diseases, while the underlying molecular mechanism still remains uncertain. Here, the human embryonic stem cell line (H7-BMP10del) with homozygous deletion of BMP10 was generated by CRISPR/Cas9 method. Thus, the crosstalk related to BMP10 signaling could be investigated in cell fate determination and the molecular pathogenesis of cardiovascular disease.
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