医学
列线图
肺癌
内科学
阶段(地层学)
曼惠特尼U检验
多元分析
临床意义
肺
高分辨率计算机断层扫描
放射科
胃肠病学
肿瘤科
核医学
生物
古生物学
作者
Xiaoli Guo,Jingjing Shao,Baoqian Zhai,Qijiu Zou,Jiaxin Yan,Hao Gu,Wang Gaoren
标识
DOI:10.1016/j.ejrad.2020.109039
摘要
Purpose This study was conducted to assess the relationship and prognostic significance between preoperative serum albumin to globulin ratio (AGR) and high-resolution computed tomography (HRCT) features of non-small cell lung cancer (NSCLC). Materials and methods Demographic parameters, laboratory values including AGR and other clinical variables were evaluated in 180 patients with NSCLC, and 72 of these patients had results of radiology parameters detected with HRCT [including emphysema, tumor disappearance rate (TDR), CT values and CT enhanced values of the tumor mass] were assessed for survival analyses. The 72 patients were divided into two groups: normal lung group and emphysema group. The discriminatory values for AGR between these two groups were assessed by Mann–Whitney U test The relationship between TDR and AGR in NSCLC patients was evaluated by Pearson correlation analysis. Results In multivariate analysis, TDR (p = 0.033), AGR (p = 0.038), emphysema (p = 0.009), and N stage (P = 0.026) were independent predictors of overall survival (OS). AGR was higher in NSCLC patients without emphysema than NSCLC patients with emphysema (z = −2.979, P = 0.003). TDR demonstrated that there was a positive relationship with AGR (r = 0.307, p = 0.009). A nomogram with AGR, TDR, emphysema, and N stage was established to predict 5-year survival. Conclusions There is a relationship between CT features and AGR in NSCLC. The integrative nomogram combined with CT images, clinical and hematologic features improved survival prediction in NSCLC patients, which offers a non-invasive, comprehensive, and convenient evaluation for individualized management of NSCLC patients.
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