医学
阴道镜检查
宫颈上皮内瘤变
回顾性队列研究
内科学
宫颈癌
辅助治疗
佐剂
癌症
肿瘤科
作者
P Stentella,Alberto Biamonti,Carlo Carraro,Paolo Inghirami,Pasquale Mancino,Daniela Pietrangeli,Sergio Votano,Paola De Lazzari,Caterina De Medici
出处
期刊:Minerva obstetrics and gynecology
[Edizioni Minerva Medica]
日期:2017-07-01
卷期号:69 (5)
被引量:4
标识
DOI:10.23736/s0026-4784.17.04053-9
摘要
Persistent human papillomavirus (HPV) infection constitutes the principal risk factor for the development of cervical intraepithelial neoplasia (CIN) and cervical cancer. For this reason, new drugs have been studied to support the host immune system against the HPV infection. The aim of this retrospective, case-control study was to detect the efficacy and safety of carboxymethyl β-glucan (Colpofix®) gel as adjuvant therapy in HPV infection.The medical records of patients attending the Colposcopy Service of four hospitals in Rome from 2011 to 2013 were collected. Case arm consisted of patients submitted to local therapy with Colpofix®. Control arm comprised patients who did not receive this therapy. A total of 999 patients were included, divided into four groups, according to their cytological and histological specimens, colposcopy and subsequent management.Local therapy with Colpofix® gel resulted effective with respect to no therapy for the regression of low-grade CIN (CIN1) in patients submitted to follow up (P=0.0204), while it was no effective for the regression of CIN1 submitted to ablative therapy and high-grade CIN (CIN 2+) (P value not significant).In conclusion, Colpofix® gel represents a valid alternative to "wait and see" strategy in patients affected by CIN1. Further prospective studies are warranted to confirm these results.
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