灰树花
Wnt信号通路
体内
结直肠癌
髓过氧化物酶
一氧化氮
化学
癌症研究
超氧化物歧化酶
药理学
结肠炎
肿瘤坏死因子α
免疫学
癌症
信号转导
内科学
抗氧化剂
生物化学
医学
生物
多糖
炎症
有机化学
生物技术
作者
Meng Meng,Mingzhe Guo,Pei Wang,Ran Han,Jiaping Zhou,Chunling Wang
标识
DOI:10.1016/j.jff.2019.103578
摘要
The aim of this study was to analyze the preventive effect of water-soluble polysaccharides in the maitake mushrooms (Grifola frondosa) fruiting body (GFP) on colon cancer in high-fat (HF) mice and WIDR cells. In vivo, the administration of GFP decreased colon myeloperoxidase (MPO) activity and disease activity index (DAI) compared with HF group (P < 0.05), and GFP was significantly inhibited the nitric oxide (NO) while increased of L-Glutathione (GSH) and superoxide dismutase (SOD). The expression of COX-2、IL-6、TNF-α was decreased in GFP -treated group, and the expression of lnterleukin-10(IL-10) and lnterleukin-4(IL-4) was increased. In addition, GFP can regulate the Wnt/β-catenin/GSK-3β signaling pathway to achieve the inhibitory effect on the survival of colon cancer. And CPS-II had high selectivity to tumor cells in vitro. The results revealed that CPS-II can inhibit colon cancer growth in vitro and in vivo, and may be a novel therapeutic agent for the disease.
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