Research advances in the role of polyamine metabolism in aging and heart failure

The incidence of aging-induced heart failure has increased.Spermidine, spermine, and putrescine, the intermediate metabolites of polyamine metabolism, not only participate in an array of crucial molecular interactions with DNA, RNA, and proteins involved in gene transcription and cell division, but also change with aging and age-associated cardiac dysfunction.Detection of serum polyamine metabolites and B type natriuretic peptide(BNP)may open up new ways for the assessment of aging and aging-induced cardiac dysfunction. Key words: Polyamines; Aging; Heart failure; Prognosis