化学
聚糖
糖复合物
糖基化
生物化学
寄主(生物学)
糖蛋白
生物
生态学
作者
Hirokazu Yagi,Naoko Yasukawa,Shin-Yi Yu,Chao-Tan Guo,Noriko Takahashi,Tadanobu Takahashi,Wakoto Bukawa,Takashi Suzuki,Kay-Hooi Khoo,Yasuo Suzuki,Koichi Kato
标识
DOI:10.1016/j.carres.2008.03.031
摘要
Edible bird's nest (EBN) is the nest made from the saliva of Collocalia swift. Recently, we have found that EBN extract could strongly inhibit infection of influenza viruses in a host-range-independent manner [Guo, C. T.; Takahashi, T.; Bukawa, W.; Takahashi, N.; Yagi, H.; Kato, K.; Hidari, K. I.; Miyamoto, D.; Suzuki, T.; Suzuki, Y. Antiviral Res.2006, 70, 140-146]. Although this antiviral activity might be attributed to O- or N-glycoconjugates, no N-glycan structures have so far been described for EBN. Here, we report the N-glycosylation profile of EBN, in which a tri-antennary N-glycan bearing the alpha2,3-N-acetylneuraminic acid residues is displayed as a major component. We suggest that the sialylated high-antennary N-glycans of EBN contribute to the inhibition of influenza viral infection.
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