细菌性阴道病
医学
怀孕
优势比
置信区间
产科
维生素D与神经学
逻辑回归
全国健康与营养检查调查
风险因素
维生素D缺乏
妇科
内科学
人口
环境卫生
生物
遗传学
作者
Katherine J. Hensel,Tara M. Randis,Shari E. Gelber,Adam J. Ratner
标识
DOI:10.1016/j.ajog.2010.08.013
摘要
Recent data suggest vitamin D deficiency (VDD) is associated with bacterial vaginosis (BV) during pregnancy. We hypothesized that VDD is a risk factor for BV in nonpregnant women.Using National Health and Nutrition Examination Survey data, we conducted multivariable logistic regression analyses stratified by pregnancy.VDD was associated with BV only in pregnant women (adjusted odds ratio [AOR], 2.87; 95% confidence interval [CI], 1.13-7.28). Among nonpregnant women, douching (AOR, 1.72; 95% CI, 1.25-2.37), smoking (AOR, 1.66; 95% CI, 1.23-2.24), and black race (AOR, 2.41; 95% CI, 1.67-3.47) were associated with BV; oral contraceptive use was inversely associated with BV (AOR, 0.60; 95% CI, 0.40-0.90). VDD moderated the association between smoking and BV in nonpregnant women.Risk factors for BV differ by pregnancy status. VDD was a modifiable risk factor for BV among pregnant women; evaluation of vitamin D supplementation for prevention or adjunct therapy of BV in pregnancy is warranted.
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