Halogen Azide Displacement to Prepare Some Symmetrically Substituted β‐Cyclodextrin Derivatives

Abstract The heptakis (2,3‐di‐O‐acetyl‐6‐bromo‐6‐deoxy)‐β‐cyclodextrin has been converted to the 6‐azido derivate with 82% yield, then deacetylated by the Zemplén 's method (yield 75%) and methylated by methyl‐iodide (yield 66%), to heptakis (2,3‐di‐O‐methyl‐6‐azido‐6‐deoxy)‐β‐cyclodextrin, which is an appropriate intermediary toward methylated amino‐CD‐derivatives. The structure of all compounds were unambiguously proven by NMR spectroscopy.