‘Naked-eye’ colorimetric/fluorimetric detection of F− ions by biologically active 3-((1H-indol-3-yl)methyl)-4-hydroxy-2H-chromen-2-one derivatives

An improved synthetic protocol has been developed to construct highly functionalized heterologous alkyl and benzyl indolyl-coumarin derivatives using a rapid, catalyst-free and solvent-free one-pot three-component reaction of indole, aldehyde and 4-hydroxy-coumarin.