Creation of a Feline Model of Obstructive Uropathy

No AccessJournal of Urology1 Apr 1991Creation of a Feline Model of Obstructive Uropathy Charles Radzinski, Edward J. McGuire, Diane Smith, Alan J. Wein, Robert M. Levin, Larry F. Miller, and Ahmad Elbadawi Charles RadzinskiCharles Radzinski More articles by this author , Edward J. McGuireEdward J. McGuire More articles by this author , Diane SmithDiane Smith More articles by this author , Alan J. WeinAlan J. Wein More articles by this author , Robert M. LevinRobert M. Levin More articles by this author , Larry F. MillerLarry F. Miller More articles by this author , and Ahmad ElbadawiAhmad Elbadawi More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38478-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The aim of this project was to create a reproducible, quantifiable feline model of obstructive uropathy. Seventy-three adult female cats of comparable age were evaluated to obtain the normal control urodynamic data base. Twenty-four cats had a silastic cuff installed around the urethra to induce bladder outlet obstruction, and eight underwent a sham operation. Repeated urodynamic evaluations were performed at predetermined postoperative intervals. The obstructed and normal cats inhibited detrusor contractility by reflex striated urethral sphincter activity. Measurements of voiding pressure to verify the presence, and to assess the degree of induced outlet obstruction, required paralysis of the sphincter by curare. Following cuff implantation, voiding pressure increased from a mean normal of 17.2cm./H2O to 31.6 to 42.5cm./H2O in animals designated as moderately obstructed, and to 101.7-125.0cm./H2O in animals designated as severely obstructed. 84.6% of the high pressure bladders developed vesicoureteral reflux. Analysis of resting, low bladder volume, urethral pressure profile (UPP) data and voiding pressures indicate a compensatory sphincteric response to filling in non-curarized animals, and a lack of that response in curarized animals. It appears that implantation of a silastic cuff to prevent full opening of the urethra during voiding, without actually compressing it, is a reasonable model of obstructive uropathy. The observation that the relationship between striated urethral sphincter activity and inhibition of detrusor contractility is influenced by administration of curare was unexpected, and may have clinical implications. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByLEMACK G, BURKHARD F, ZIMMERN P, MCCONNELL J and LIN V (2018) PHYSIOLOGIC SEQUELAE OF PARTIAL INFRAVESICAL OBSTRUCTION IN THE MOUSE: ROLE OF INDUCIBLE NITRIC OXIDE SYNTHASEJournal of Urology, VOL. 161, NO. 3, (1015-1022), Online publication date: 1-Mar-1999.O'Connor L, Vaughan E and Felsen D (2018) In Vivo Cystometric Evaluation of Progressive Bladder Outlet Obstruction in RatsJournal of Urology, VOL. 158, NO. 2, (631-635), Online publication date: 1-Aug-1997.Guan Z, Kiruluta G, Coolsaet B and Elhilali M (2018) A Minipig Model for Urodynamic Evaluation of Infravesical Obstruction and its Possible ReversibilityJournal of Urology, VOL. 154, NO. 2, (580-586), Online publication date: 1-Aug-1995.Levin R, Longhurst P, Barasha B, McGuire E, Elbadawi A and Wein A (2018) Studies on Experimental Bladder Outlet Obstruction in the Cat: Long-Term Functional EffectsJournal of Urology, VOL. 148, NO. 3 Part 1, (939-943), Online publication date: 1-Sep-1992. Volume 145Issue 4April 1991Page: 859-863 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordsurinary bladderstriated urethral sphincterurodynamicsoutlet obstructioncatfluoroscopymicturitionMetricsAuthor Information Charles Radzinski More articles by this author Edward J. McGuire More articles by this author Diane Smith More articles by this author Alan J. Wein More articles by this author Robert M. Levin More articles by this author Larry F. Miller More articles by this author Ahmad Elbadawi More articles by this author Expand All Advertisement PDF DownloadLoading ...