发病机制
生物
病毒学
病毒
病态的
滴答声
免疫学
病理
医学
作者
Xiao-Ping Chen,Mei-Li Cong,Minghui Li,Yijun Kang,Yange Feng,Alexander Plyusnin,Jianguo Xu,Yǒng-Zhèn Zhāng
标识
DOI:10.1099/vir.0.041053-0
摘要
A novel tick-borne bunyavirus (Huaiyangshan virus, HYSV), which causes haemorrhagic fever-like disease, has recently been reported in China. So far no animal experiments have been performed to study its pathogenesis. Towards developing an animal model for HYSV fever, newborn and adult mice and rats and golden hamsters were inoculated intracerebrally or intraperitoneally with HYSV. Newborn rats and newborn mice, especially Kunming (KM) mice, appeared highly susceptible. Remarkably, the KM mice that died of the HYSV infection developed large necrotic areas in the liver, while no obvious pathological changes were observed within the other organs. PCR and immunohistochemical analyses of the post-mortem material detected both HYSV antigen and RNA in almost all organs, indicating a systemic infection. Our data demonstrate that HYSV can cause a lethal infection of both newborn mice and newborn rats with apparent pathological damage of the liver. This animal model may help to understand the pathogenesis of the HYSV infection in humans.
科研通智能强力驱动
Strongly Powered by AbleSci AI