尿检
毒性
医学
血液学
生理学
内科学
毒理
药理学
尿
生物
作者
Zhong Han,Hao Xu,Kwang Ho Kim,Tae Hwan Ahn,Jin Sook Bae,Ji Young Lee,Ki Hyun Gil,Joo Young Lee,Su Jung Woo,Hyun Jung Yoo,Hyun Kul Lee,Kap Ho Kim,Chan Koo Park,Hu Song Zhang,Si Whan Song
标识
DOI:10.5625/lar.2010.26.2.153
摘要
The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to “the standards of Toxicity Study for Medicinal Products” (2005) and The KFDA Notification No. 2000-63 ‘Good Laboratory Practice (GLP)’ (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.
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