干扰素基因刺激剂
先天免疫系统
刺
炎症
医学
生物
免疫系统
疾病
干扰素
基因
获得性免疫系统
免疫
免疫学
转录因子
遗传学
航空航天工程
病理
工程类
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2015-11-25
卷期号:15 (12): 760-770
被引量:932
摘要
Activation of STING (stimulator of interferon genes) by cytosolic aberrant DNA species or cyclic dinucleotides triggers transcription of numerous innate immune genes. In this Review, the author summarizes recent insights into the regulation of STING signalling and its role in autoinflammatory disease and cancer. The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications — not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.
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