淋巴
淋巴结间质细胞
淋巴结
C-C趋化因子受体7型
病理
细胞生物学
生物
免疫学
医学
趋化因子
趋化因子受体
免疫系统
作者
Asolina Braun,Tim Worbs,Georgios Leandros Moschovakis,Stephan Halle,Katharina Hoffmann,Jasmin Bölter,Anika Münk,Reinhold Förster
摘要
Little is known about the molecular mechanisms that determine the entry into the lymph node and intranodal positioning of lymph-derived cells. By injecting cells directly into afferent lymph vessels of popliteal lymph nodes, we demonstrate that lymph-derived T cells entered lymph-node parenchyma mainly from peripheral medullary sinuses, whereas dendritic cells (DCs) transmigrated through the floor of the subcapsular sinus on the afferent side. Transmigrating DCs induced local changes that allowed the concomitant entry of T cells at these sites. Signals mediated by the chemokine receptor CCR7 were absolutely required for the directional migration of both DCs and T cells into the T cell zone but were dispensable for the parenchymal entry of lymph-derived T cells and dendrite probing of DCs. Our findings provide insight into the molecular and structural requirements for the entry into lymph nodes and intranodal migration of lymph-derived cells of the immune system.
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