[Advances in the research of application of metabonomics in the treatment of severe burn or trauma].

Metabolic disorder is one of the most obvious pathophysiological characteristics of patients with severe burn or trauma, which leads to high mortality of patients with severe burn or trauma. Metabonomics is a newly developed subject which provides new research concepts and ideas for studying the changes of metabolism in a disease condition. Based on the analysis of group indicators, metabonomic technique not only can systematically study the change rules of metabolites, which helps to further clarify the pathophysiological mechanism of burn or trauma, but also is helpful to find some significant biomarkers with important clinical value so as to provide new insight for the therapy of burn or trauma. This paper reviews the research progress of application of metabonomics in the treatment of severe burn or trauma in recent years.代谢紊乱是危重烧创伤患者最明显的病理生理特征之一，也是导致危重烧创伤患者高病死率的重要因素之一。代谢组学是一门新发展起来的学科，为研究机体代谢在疾病状况下的改变提供了新的理念和思路。代谢组学技术以组群指标分析为基础，不仅有助于系统研究代谢产物的变化规律，从而进一步阐明烧创伤的病理生理机制；还可以帮助发现某些具有重要临床价值的生物标志物，从而为烧创伤的治疗提供方向。本文就近年来代谢组学在危重烧创伤救治中的应用研究进展进行综述。.