结直肠癌
生物
癌症
转移
基因组
癌症研究
医学
基因
遗传学
作者
María González‐González,María Laura Gutiérrez,José María Sayagués,Luís Muñoz‐Bellvís,Alberto Órfão
标识
DOI:10.1016/j.semcancer.2020.05.013
摘要
Sporadic colorectal cancer (sCRC) is the third leading cause of cancer death in the Western world. Approximately, a quarter of sCRC patients present metastatic dissemination at the moment of diagnosis, the liver being the most frequently affected organ. Additionally, this group of CRC patients is characterized by a worse prognosis. In the last decades, significant technological developments for genome analysis have fostered the identification and characterization of genetic alterations involved in the pathogenesis of sCRC. However, genetic alterations involved in the metastatic process through which tumor cells are able to colonize other tissues with a different microenvironment, still remain to be fully identified. Here, we review current knowledge about the most relevant genomic alterations involved in the liver metastatic process of sCRC, including detailed information about the genetic profile of primary colorectal tumors vs. their paired liver metastases.
科研通智能强力驱动
Strongly Powered by AbleSci AI