材料科学
光子上转换
光热治疗
介孔材料
氧化锡
生物相容性
过氧化氢
纳米壳
纳米颗粒
纳米技术
光电子学
冶金
兴奋剂
催化作用
有机化学
化学
作者
Lili Feng,Ruoxi Zhao,Bin Liu,Shili Gai,Yujin Chen,Piaoping Yang
标识
DOI:10.1021/acsami.0c10685
摘要
Tumor hypoxia compromises the therapeutic efficacy of oxygen (O2)-dependent treatment methods as the endogenous O2 levels have an important influence on the production of reaction oxygen species. Herein, a synergistic multifunctional mesoporous Fe@Sn-UCNPs bio-photocatalytic nanoplatform is provided to comprehensively realize endogenous hydrogen peroxide (H2O2)-activatable, self-supplied O2, photothermal performance, and near-infrared-mediated magnetic targeting PDT/PTT simultaneously for relieving tumor hypoxia. Such a nanoplatform is constructed by encapsulating magnetic Fe3O4 with lanthanide-ion-doped mesoporous tin oxide upconversion nanoparticles and further modified with phosphorylated serine and poly(ethylene glycol) for enhancing the biocompatibility and solubility. The nanoparticles can be activated by endogenous H2O2 and in situ generated O2 to relieve hypoxia through catalytic reaction. Therefore, H2O2-responsive/O2-evolving nanoparticles can elevate the O2 level in the tumor site for an apparently enhanced PDT effect in vitro and in vivo. What is more, Fe@Sn-UCNPs demonstrate enhanced photothermal conversion efficiency based on the special nanostructure and much more circuit loops for electron transitions between Fe3O4 and Sn-UCNPs, and the electronic structure of Fe@Sn-UCNPs was calculated. In addition, such Fe@Sn-UCNPs also exhibit multimodality imaging performance (including photothermal, magnetic resonance, and computed tomography imaging) for monitoring and tracking the in vivo tumor therapeutic process. This work provides novel insight into the smart Fe@Sn-UCNPs as an "all-in-one" theranostic nanosystem for cancer therapy.
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