材料科学
PLGA公司
生物医学工程
复合材料
极限抗拉强度
降级(电信)
作者
Magdalena Kobielarz,Magdalena Tomanik,Katarzyna Mroczkowska,Konrad Szustakiewicz,Magdalena Oryszczak,Anna Mazur,Arkadiusz J. Antończak,Jarosław Filipiak
出处
期刊:Acta of Bioengineering and Biomechanics
[Politechnika Wroclawska Oficyna Wydawnicza]
日期:2020-01-01
卷期号:22 (1): 179-197
被引量:3
标识
DOI:10.37190/abb-01532-2019-02
摘要
PURPOSE Irradiations by CO2 laser poly(lactic-co-glycolic acid) surface lead to alterations of physicochemical properties of a copolymer. Effects of PLGA irradiations are results of photochemical and photothermal processes leading to polymer degradation. The scale of the degradation depends on the inducted surface modification. Hence the main goal of presented studies was to define the influence of CO2 laser irradiation with different process parameters, inducing three cases of surface modification, on mechanical properties and topography of PLGA during degradation in the aqueous environment. METHODS Hydrolytic degradation were performed in distilled (demineralized) water. Mechanical properties were conducted in accordance with the PN-EN ISO 527-3:1998 standard. pH of incubating solution, specimens' topography, mass and geometrical dimensions were controlled during process. RESULTS During the hydrolytic degradation, gradual changes in failure mode were observed from ductile failure characteristic for untreated PLGA to brittle failure of incubated PLGA regardless of the case of triggered modification. Tensile strength decreased with degradation time regardless of the case of surface modification with insignificant fluctuation in means Young's moduli. pH for each case decreased and topography od specimens become smoother with incubation time. CONCLUSIONS PLGA surface modification by CO2 laser below the ablation threshold (P1) and at the ablation threshold (P2) leaded to surface functionalization, however, irradiation above the ablation threshold (P3) caused marked degradation of PLGA and accelerated specimens disintegration during incubation in the aquatic environment.
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