酶原
蛋白质C
蛇毒
凝血酶
化学
毒液
生物化学
激活剂(遗传学)
因子X
蛋白酶
酶
血栓调节蛋白
蛋白质S
凝血因子
胰蛋白酶
凝结
分子生物学
生物
血小板
免疫学
医学
受体
内科学
精神科
作者
Andleeb Asmat,Faiqah Ramzan
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2018-09-06
被引量:8
标识
DOI:10.2174/0929866525666180619101218
摘要
Protein C is a vitamin K dependent plasma zymogen. It inhibits clotting by inhibiting clotting by inactivating factor V and factor VIII. Protein C activation pathway involves three steps: (i) Activation of protein C; (ii) Inhibition of coagulation through inactivating factor V and VIII by activated protein C and (iii) Inhibition of activated protein C by plasma protease inhibitors specific for this enzyme. Proteinases converting the zymogen protein C (PC) of vertebrates into activated PC have been detected in several snake venoms. Most PC activators have been purified from venom of snake species belonging to the genera of the Agkistrodon complex. Unlike the physiological thrombin-catalyzed PC activation reaction which requires thrombomodulin as a cofactor, most snake venom activators directly convert the zymogen PC into the catalytically active form which can easily be determined by means of coagulation or chromogenic substrate techniques.The fast-acting PC activator Protac® from Agkistrodon contortrix contortrix (Southern copperhead snake) venom has found a broad application in diagnostic practice for the determination of disorders in the PC pathway. Recently, screening assays for the PC pathway have been introduced, based on the observation that the PC pathway is probably the most important physiological barrier against thrombosis.
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