青霉属
海洋真菌
抗菌剂
生物
鲍曼不动杆菌
枯草芽孢杆菌
微生物学
腐败舍瓦内拉菌
抗菌活性
微生物
化学
细菌
植物
遗传学
铜绿假单胞菌
作者
Peter M. Eze,Ying Gao,Yang Liu,Lasse van Geelen,Ejikeugwu Chika,Charles Okechukwu Esimone,Festus Basden Chiedu Okoye,Peter Proksch,Rainer Kalscheuer
出处
期刊:Notulae Scientia Biologicae
[University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca]
日期:2021-09-09
卷期号:13 (3): 11020-11020
被引量:4
摘要
Extremophilic fungi have received considerable attention recently as new promising sources of biologically active compounds with potential pharmaceutical applications. This study investigated the secondary metabolites of a marine-derived Penicillium ochrochloron isolated from underwater sea sand collected from the North Sea in St. Peter-Ording, Germany. Standard techniques were used for fungal isolation, taxonomic identification, fermentation, extraction, and isolation of fungal secondary metabolites. Chromatographic separation and spectroscopic analyses of the fungal secondary metabolites yielded eight compounds: talumarin A (1), aspergillumarin A (2), andrastin A (3), clavatol (4), 3-acetylphenol (5), methyl 2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furanpropanoate (6), emodin (7) and 2-chloroemodin (8). After co-cultivation with Bacillus subtilis, the fungus was induced to express (-)-striatisporolide A (9). Compound 1 was evaluated for antibacterial activity against Staphylococcus aureus, Acinetobacter baumannii, Mycobacterium smegmatis, and M. tuberculosis, as well as cytotoxicity against THP-1 cells. The compound, however, was not cytotoxic to THP-1 cells and had no antibacterial activity against the microorganisms tested. The compounds isolated from P. ochrochloron in this study are well-known compounds with a wide range of beneficial biological properties that can be explored for pharmaceutical, agricultural, or industrial applications. This study highlights the bioprospecting potential of marine fungi and confirms co-cultivation as a useful strategy for the discovery of new natural products.
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