光敏剂
光动力疗法
线粒体
活性氧
化学
氧气
生物物理学
缺氧(环境)
细胞呼吸
生物化学
光化学
生物
有机化学
作者
Liping Zuo,Weidong Nie,Songmao Yu,Wan-Ru Zhuang,Guanghao Wu,Houli Liu,Lili Huang,Danshu Shi,Xin Sui,Yongheng Li,Hai‐Yan Xie
标识
DOI:10.1002/anie.202109258
摘要
Positioning essential elements of photodynamic therapy (PDT) near to mitochondria can conquer the rigorous spatiotemporal limitations of reactive oxygen species (ROS) transfer and make considerable differences in PDT. However, precise accumulation of photosensitizer (PS) and oxygen within mitochondria is still challenging. We simultaneously encapsulated hexyl 5-aminolevulinate hydrochloride (HAL) and 3-bromopyruvic acid (3BP) into microparticles collected from X-ray-irradiated tumor cells (X-MP). After systemic administration, the developed HAL/3BP@X-MP can specifically target and recognize tumor cells, where HAL induces efficient accumulation of PpIX in mitochondria via the intrinsic haem biosynthetic pathway. Meanwhile, 3BP remarkably increases the oxygen supply by inhibiting mitochondrial respiration. The accurate co-localization and prompt encounter of PpIX and oxygen produce sufficient ROS to directly disrupt mitochondria, resulting in significantly improved PDT outcomes.
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