体内
聚乙二醇
纳米颗粒
PEG比率
药物输送
纳米材料
纳米技术
金属有机骨架
材料科学
化学
表面改性
药品
生物物理学
生物医学工程
组合化学
药理学
生物化学
有机化学
医学
生物技术
财务
吸附
物理化学
经济
生物
作者
Kai‐Xin Wang,Mengru Cai,Dongge Yin,Rongyue Zhu,Tingting Fu,Shilang Liao,Yuji Du,Jiahui Kong,Jian Ni,Xingbin Yin
标识
DOI:10.1016/j.jsamd.2023.100548
摘要
Polyphyllin I (PPI) is a naturally active steroidal saponin that has good therapeutic effects in various cancers, such as liver and lung cancers. However, owing to its non-selective distribution in various tissues, it is toxic and has side effects on normal human organs while taking effect. To solve this problem, a unique functionalized nanomaterial called metal–organic frameworks (MOFs) was prepared as a targeted nanoparticle for tumor therapy. MOFs are porous coordination polymers that can achieve precise structural and functional adjustability by regulating the organic ligands and metal ions. IRMOF-8 with a multidimensional network topology whose aperture matched the size of PPI was selected to load the PPI. In this study, PPI was loaded into IRMOF-8 via ex situ encapsulation. Drug-loaded nanoparticles (NPs) were coated with polyethylene glycol (PEG) coupled to cell-penetrating peptides (CPPs). The obtained nanoplatform denoted as PEG-CPP44/[email protected] NPs had a spherical shape, a rough and uneven surface, an average particle size of 202.97 nm, excellent drug loading (33.37%), and showed release behavior. In addition, the NPs showed remarkable targeting selectivity for cellular uptake and in vivo imaging. More importantly, it exhibited good antitumor activity in vivo and in vitro. It not only increased the therapeutic efficiency of PPI for liver cancer but also reduced the damage caused by PPI to normal organs. The preparation of the functional nanoplatform (PEG-CPP44/[email protected]) shows the advantages and highlights of MOF-based drug delivery systems and can help in the follow-up precise treatment of tumors.
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