应力颗粒
转录组
蛋白质组
生物
细胞生物学
颗粒(地质)
免疫系统
蛋白质组学
基因表达
基因
免疫学
信使核糖核酸
遗传学
翻译(生物学)
古生物学
作者
Nicolas Curdy,Olivia Lanvin,Juan‐Pablo Cerapio,Frédéric Pont,Marie Tosolini,Emeline Sarot,Carine Valle,Nathalie Saint-Laurent,Émeline Lhuillier,Camille Laurent,Jean‐Jacques Fournié,Don-Marc Franchini
出处
期刊:Cell Reports
[Elsevier]
日期:2023-03-01
卷期号:42 (3): 112211-112211
被引量:2
标识
DOI:10.1016/j.celrep.2023.112211
摘要
Stress granules (SGs) and processing bodies (PBs) are membraneless cytoplasmic assemblies regulating mRNAs under environmental stress such as viral infections, neurological disorders, or cancer. Upon antigen stimulation, T lymphocytes mediate their immune functions under regulatory mechanisms involving SGs and PBs. However, the impact of T cell activation on such complexes in terms of formation, constitution, and relationship remains unknown. Here, by combining proteomic, transcriptomic, and immunofluorescence approaches, we simultaneously characterized the SGs and PBs from primary human T lymphocytes pre and post stimulation. The identification of the proteomes and transcriptomes of SGs and PBs indicate an unanticipated molecular and functional complementarity. Notwithstanding, these granules keep distinct spatial organizations and abilities to interact with mRNAs. This comprehensive characterization of the RNP granule proteomic and transcriptomic landscapes provides a unique resource for future investigations on SGs and PBs in T lymphocytes.
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