Response by Dhingra et al to Letter Regarding Article, “Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy”

HomeCirculationVol. 147, No. 13Response by Dhingra et al to Letter Regarding Article, “Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy” No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextResponse by Dhingra et al to Letter Regarding Article, “Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy” Rimpy Dhingra, Ali Javaheri, Abhinav Diwan and Lorrie A. Kirshenbaum Rimpy DhingraRimpy Dhingra The Institute of Cardiovascular Sciences, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada (R.D., L.A.K.). Departments of Physiology and Pathophysiology (R.D., L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. Search for more papers by this author , Ali JavaheriAli Javaheri https://orcid.org/0000-0001-6657-331X Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO (A.J., A.D.). Search for more papers by this author , Abhinav DiwanAbhinav Diwan https://orcid.org/0000-0001-7554-4772 Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO (A.J., A.D.). Search for more papers by this author and Lorrie A. KirshenbaumLorrie A. Kirshenbaum https://orcid.org/0000-0002-9617-5803 The Institute of Cardiovascular Sciences, St Boniface Hospital Albrechtsen Research Centre, Winnipeg, Canada (R.D., L.A.K.). Departments of Physiology and Pathophysiology (R.D., L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. Pharmacology and Therapeutics (L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. Search for more papers by this author Originally published27 Mar 2023https://doi.org/10.1161/CIRCULATIONAHA.123.063546Circulation. 2023;147:1051–1052"Response by Dhingra et al to Letter Regarding Article, “Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy”." Circulation, 147(13), pp. 1051–1052FootnotesCirculation is available at www.ahajournals.org/journal/circReferences1. Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela Ripoll C, et al. Proteasomal degradation of TRAF2 mediates mitochondrial dysfunction in doxorubicin-cardiomyopathy.Circulation. 2022; 146:934–954. doi: 10.1161/CIRCULATIONAHA.121.058411LinkGoogle Scholar2. Siegmund D, Wagner J, Wajant H. TNF receptor associated factor 2 (TRAF2) signaling in cancer.Cancers (Basel). 2022; 14:4055–4083. doi: 10.3390/cancers14164055CrossrefMedlineGoogle Scholar3. Gang H, Dhingra R, Lin J, Hai Y, Aviv Y, Margulets V, Hamedani M, Thanasupawat T, Leygue E, Klonisch T, et al. PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival.J Cell Biol. 2015; 210:1101–1115. doi: 10.1083/jcb.201504047CrossrefMedlineGoogle Scholar4. Ichikawa Y, Ghanefar M, Bayeva M, Wu R, Khechaduri A, Naga Prasad SV, Mutharasan RK, Naik TJ, Ardehali H. Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation.J Clin Invest. 2014; 124:617–630. doi: 10.1172/JCI72931CrossrefMedlineGoogle Scholar5. Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, Dorn GW, Kirshenbaum LA. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.Proc Natl Acad Sci USA. 2014; 111:E5537–E5544. doi: 10.1073/pnas.1414665111CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails March 28, 2023Vol 147, Issue 13 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.063546PMID: 36972342 Originally publishedMarch 27, 2023 PDF download Advertisement SubjectsBasic Science ResearchCardiomyopathyCardiotoxicityHeart FailureMechanisms