Fibrotic remodeling and tissue regeneration mechanisms define the therapeutic potential of human muscular progenitors

再生(生物学) 纤维化 祖细胞 旁分泌信号 伤口愈合 医学 祖细胞 细胞生物学 细胞外基质 干细胞 生物 病理 癌症研究 免疫学 内科学 受体
作者
Ya‐Chuan Hsiao,I‐Han Wang,Tsung‐Lin Yang
出处
期刊:Bioengineering & translational medicine [Wiley]
卷期号:8 (2)
标识
DOI:10.1002/btm2.10439
摘要

Fibrosis is an intrinsic biological reaction toward the challenges of tissue injury that is implicated in the wound-healing process. Although it is useful to efficiently mitigate the damage, progression of fibrosis is responsible for the morbidity and mortality occurring in a variety of diseases. Because of lacking effective treatments, there is an emerging need for exploring antifibrotic strategies. Cell therapy based on stem/progenitor cells is regarded as a promising approach for treating fibrotic diseases. Appropriate selection of cellular sources is required for beneficial results. Muscle precursor cells (MPCs) are specialized progenitors harvested from skeletal muscle for conducting muscle regeneration. Whether they are also effective in regulating fibrosis has seldom been explored and merits further investigation. MPCs were successfully harvested from all human samples regardless of demographic backgrounds. The extracellular matrices remodeling was enhanced through the paracrine effects mediated by MPCs. The suppression effects on fibrosis were confirmed in vivo when MPCs were transplanted into the diseased animals with oral submucous fibrosis. The data shown here revealed the potential of MPCs to be employed to simultaneously regulate both processes of fibrosis and tissue regeneration, supporting them as the promising cell candidates for development of the cell therapy for antifibrosis and tissue regeneration.
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