转甲状腺素
医学
心脏淀粉样变性
磁共振成像
心肌病
疾病
闪烁照相术
淀粉样变性
心脏成像
心力衰竭
淀粉样蛋白(真菌学)
心脏病学
病理
内科学
放射科
作者
Louhai Alwan,Dominik C. Benz,Sarah Cuddy,Stephan Dobner,Isaac Shiri,Federico Caobelli,Benedikt Bernhard,Simon F. Stämpfli,Franz R. Eberli,Mauricio Reyes,Raymond Y. Kwong,Rodney H. Falk,Sharmila Dorbala,Christoph Gräni
标识
DOI:10.1016/j.jcmg.2023.10.010
摘要
Amyloid transthyretin (ATTR) amyloidosis is a protein-misfolding disease characterized by fibril accumulation in the extracellular space that can result in local tissue disruption and organ dysfunction. Cardiac involvement drives morbidity and mortality, and the heart is the major organ affected by ATTR amyloidosis. Multimodality cardiac imaging (ie, echocardiography, scintigraphy, and cardiac magnetic resonance) allows accurate diagnosis of ATTR cardiomyopathy (ATTR-CM), and this is of particular importance because ATTR-targeting therapies have become available and probably exert their greatest benefit at earlier disease stages. Apart from establishing the diagnosis, multimodality cardiac imaging may help to better understand pathogenesis, predict prognosis, and monitor treatment response. The aim of this review is to give an update on contemporary and evolving cardiac imaging methods and their role in diagnosing and managing ATTR-CM. Further, an outlook is presented on how artificial intelligence in cardiac imaging may improve future clinical decision making and patient management in the setting of ATTR-CM.
科研通智能强力驱动
Strongly Powered by AbleSci AI