试剂
化学
分子内力
亚砜
组合化学
二甲基亚砜
有机化学
作者
Wen Li,Huilin Lan,Jinfa Huang,Wenting Liu,Kezhi Jiang,Xu‐Qiong Xiao,Shao‐Fei Ni,Jingsong Liu,Ying Bai,Xinxin Shao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-01-18
卷期号:26 (3): 687-691
标识
DOI:10.1021/acs.orglett.3c04082
摘要
A new, stable and scalable reagent based on a sulfoxide skeleton for direct deuteriodifluoromethylthiolation has been developed. The reagent displays excellent reactivities toward Tf2O promoted C–H deuteriodifluoromethylthiolation of electron-rich arenes, indoles, alkenes, and intramolecular lactonization of 2-alkynylbenzoates. Moreover, high deuteration rates and good to excellent yields were achieved under metal-free reaction conditions. As a result, a wide range of deuteriodifluoromethylthilolated compounds were prepared, enabling further applications in drug discovery.
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