骨关节炎
干细胞
医学
再生医学
间充质干细胞
干细胞疗法
再生(生物学)
软骨
细胞疗法
生物信息学
外科
重症监护医学
病理
生物
解剖
替代医学
细胞生物学
遗传学
作者
Michael Thoene,Ewa Bejer-Oleńska,Joanna Wojtkiewicz
摘要
Articular cartilage has very low metabolic activity. While minor injuries may be spontaneously repaired within the joint by chondrocytes, there is very little chance of a severely impaired joint regenerating itself when damaged. Therefore, any significant joint injury has little chance of spontaneously healing without some type of therapy. This article is a review that will examine the causes of osteoarthritis, both acute and chronic, and how it may be treated using traditional methods as well as with the latest stem cell technology. The latest regenerative therapy is discussed, including the use and potential risks of mesenchymal stem cells for tissue regeneration and implantation. Applications are then discussed for the treatment of OA in humans after using canine animal models. Since the most successful research models of OA were dogs, the first applications for treatment were veterinary. However, the treatment options have now advanced to the point where patients suffering from osteoarthritis may be treated with this technology. A survey of the literature was performed in order to determine the current state of stem cell technology being used in the treatment of osteoarthritis. Then, the stem cell technology was compared with traditional treatment options.
科研通智能强力驱动
Strongly Powered by AbleSci AI