自愈水凝胶
材料科学
乙二醇
弹性蛋白
细胞外基质
相(物质)
组织工程
化学工程
韧性
纳米技术
生物医学工程
高分子化学
复合材料
化学
有机化学
生物化学
工程类
病理
医学
作者
Shohei Ishikawa,Yuki Yoshikawa,Hiroyuki Kamata,Ung‐il Chung,Takamasa Sakai
标识
DOI:10.1021/acsami.2c09906
摘要
Injectable hydrogels are biomaterials that can be administered minimally invasively in liquid form and are considered promising artificial extracellular matrix (ECM) materials. However, ordinary injectable hydrogels are synthesized from water-soluble molecules to ensure injectability, resulting in non-phase-separated structures, making them structurally different from natural ECMs with phase-separated insoluble structural proteins, such as collagen and elastin. Here, we propose a simple material design approach to impart phase-separated structures to injectable hydrogels by adding inorganic salts. Injecting a gelling solution of mutually cross-linkable tetra-arm poly(ethylene glycol)s with potassium sulfate at optimal concentrations results in the formation of a hydrogel with phase-separated structures in situ. These phase-separated structures provide up to an 8-fold increase in fracture toughness while allowing the encapsulation of live mouse chondrogenic cells without compromising their proliferative activity. Our findings highlight that the concentration of inorganic salts is an important design parameter in injectable hydrogels for artificial ECMs.
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