芯片上器官
计算机科学
原位
炸薯条
生物传感器
生物医学工程
纳米技术
材料科学
工程类
化学
微流控
电信
有机化学
作者
Jin‐Young Kim,Jung-Hoon Kim,Yoonhee Jin,Seung‐Woo Cho
出处
期刊:Biofabrication
[IOP Publishing]
日期:2023-08-17
卷期号:15 (4): 042002-042002
被引量:2
标识
DOI:10.1088/1758-5090/aceaae
摘要
Abstract The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges accompanying in vivo experiments. Organoids and organs-on-chips have been developed to model the in vitro , real-time biological and physiological features of organs. Numerous studies have deployed these systems to assess the in vitro , real-time responses of an organ to external stimuli. Particularly, organs-on-chips can be most efficiently employed in pharmaceutical drug development to predict the responses of organs before approving such drugs. Furthermore, multi-organ-on-a-chip systems facilitate the close representations of the in vivo environment. In this review, we discuss the biosensing technology that facilitates the in situ , real-time measurements of organ responses as readouts on organ-on-a-chip systems, including multi-organ models. Notably, a human-on-a-chip system integrated with automated multi-sensing will be established by further advancing the development of chips, as well as their assessment techniques.
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