化学
氯仿
乙腈
溶剂
反应速率常数
丙酮
甲醇
光降解
光解
溶剂效应
乙酸乙酯
高效液相色谱法
粘度
丁醇
乙醇
色谱法
光化学
分析化学(期刊)
动力学
有机化学
催化作用
热力学
物理
光催化
量子力学
作者
Adeela Khurshid,Iqbal Ahmad,Nimra Khan,Muneeba Usmani,Zubair Anwar
摘要
Abstract A photodegradation study of 5‐fluorouracil (5‐FU) has been carried out in the water (pH 7.0) and organic solvents (chloroform, ethyl acetate, acetone, 1‐butanol, 1‐propanol, ethanol, methanol, and acetonitrile) using developed and validated high‐performance liquid chromatography (HPLC) method. The test method was found to be simple, accurate (% recovery, 100.25%–101.08%), precise (%RSD < 2.00), and sensitive. The apparent first‐order rate constants are in the range of 0.85 (chloroform) to 4.25 × 10 −4 min −1 (water). The values obtained for k obs were found to be linear as a function of the dielectric constant indicating the involvement of the dipolar intermediate in the reaction. The increase in the rate of degradation of this intermediate is enhanced by the polarity of the medium. Rates of photolysis for 5‐FU show a linear relationship with the solvent acceptor number (AN) which indicates the degree of solute–solvent interaction. The values of k obs were found to be linear to the inverse of the viscosity of the medium due to the diffusion‐controlled process.
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