脂筏
木筏
中心性
生物
膜蛋白
功能(生物学)
细胞生物学
蛋白质组学
计算生物学
化学
生物化学
信号转导
膜
基因
数学
有机化学
组合数学
共聚物
聚合物
作者
Ting Zhang,Xuegong Zhang,Zhirong Sun
标识
DOI:10.1016/j.jmb.2010.08.014
摘要
Lipid rafts are specialized cholesterol-enriched microdomains in the cell membrane. They have been known as a platform for protein–protein interactions and to take part in multiple biological processes. Nevertheless, how lipid rafts influence protein properties at the proteomic level is still an open question for researchers using traditional biochemical approaches. Here, by annotating the lipid raft localization of proteins in human protein–protein interaction networks, we performed a systematic analysis of the function of proteins related to lipid rafts. Our results demonstrated that lipid raft proteins and their interactions were critical for the structure and stability of the whole network, and that the interactions between them were significantly enriched. Furthermore, for each protein in the network, we calculated its “lipid raft dependency (LRD),” which indicates how close it is topologically associated with lipid rafts, and we then uncovered the connection between LRD and protein functions. Proteins with high LRD tended to be essential for mammalian development, and malfunction of these proteins was inclined to cause human diseases. Coordinated with their neighbors, high-LRD proteins participated in multiple biological processes and targeted many pathways in diseases pathogenesis. High-LRD proteins were also found to have tissue specificity of expression. In summary, our network-based analysis denotes that lipid raft proteins have higher centrality in the network, and that lipid-raft-related proteins have multiple functions and are probably concerned with many biological processes in disease development.
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